HDAC, EGFR & HER2 inhibitor
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Catalog numberB2933-5
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PricePlease ask
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Size5 mg
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Alternative_name7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide; 7-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
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DescriptionHDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with ICâ‚…â‚€ values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with ICâ‚…â‚€ values of 0.93 ÎĽM, 0.71 ÎĽM, 0.90 ÎĽM respectively.
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CAS Number1012054-55-5
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Structure AvailableTrue
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Salt Formfalse
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Molecular FormulaCâ‚‚â‚‚Hâ‚‚â‚„ClFNâ‚„Oâ‚„
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Molecular Weight462.9
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Cell PermeableTrue
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Purity95%
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SolubilitiesSoluble in DMSO in 0
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HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag LineAn HDAC, EGFR, and HER2 Inhibitor
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Storage Condition-20ÂşC
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Shipping ConditionRT
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Shelf Life36 months
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SMILESO=C(NO)CCCCCCOC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC
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InChiInChI=1S/C22H24ClFN4O4/c1-31-19-12-18-15(11-20(19)32-9-5-3-2-4-6-21(29)28-30)22(26-13-25-18)27-14-7-8-17(24)16(23)10-14/h7-8,10-13,30H,2-6,9H2,1H3,(H,28,29)(H,25,26,27)
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InChi KeyRQYVKBOWLRVISJ-UHFFFAOYSA-N
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MSDS AvailableTrue
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolEGFR-AS1, EGILA, HDAC4, EGFR, HDAC9, ERBB2, RHBDF1
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Short nameHDAC, EGFR & HER2 inhibitor
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Alternative nameHDAC, epidermal growth factor receptor & HER2 suppressor
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Alternative to gene targetepidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
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Gene info
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Identity
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Gene
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Long gene nameEGFR antisense RNA 1
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Locus
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Discovery year2012-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameEGFR interacting lncRNA
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Synonyms
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Locus
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Discovery year2019-09-27
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Pubmed identfication
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Classification
- Long non-coding RNAs with non-systematic symbols
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameepidermal growth factor receptor
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Synonyms gene
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Synonyms gene name
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
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Synonyms
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Erb-b2 receptor tyrosine kinases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameerb-b2 receptor tyrosine kinase 2
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Synonyms gene
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Synonyms gene name
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Erb-b2 receptor tyrosine kinases
- CD molecules
- Minor histocompatibility antigens
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namerhomboid 5 homolog 1
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Synonyms gene
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Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-04-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Rhomboid family
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VEGA ID