PF-06454589

• Description :

  PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].

• CAS Number :

  [1527473-30-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  LRRK2

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-06454589.html

• Purity :

  99.91

• Solubility :

  DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CN1N=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1

• Molecular Formula :

  C14H16N6O

• Molecular Weight :

  284.32

• Precautions :

  H302

• References & Citations :

  [1]Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4- (morpholin-4-yl) -7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58 (1) :419-32.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported