AZ-PRMT5i-1

CAT: 0804-HY-162783Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162783Size:1 Each
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Description
AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers[1][2].
CAS Number
[2918814-96-5]
UNSPSC
12352101
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az-prmt5i-1.html
Smiles
O=C1N(CC2=CC3=C(C=C(F)C(N)=N3)N2)[C@@]4(CCN(CC5=CC=C(F)C=C5)C4=O)C6=C1C=C(F)C=C6
Molecular Formula
C26H20F3N5O2
Molecular Weight
491.46
References & Citations
[1]Smith JM, et al. Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J Med Chem. 2024 Jul 30.|[2]Lynch J T, et al. AZ-PRMT5i-1: A potent MTAP-selective PRMT5 inhibitor with pharmacodynamic and monotherapy anti-tumor activity in MTAP-deleted tumours[J]. Cancer Research, 2023, 83 (7_Supplement) : 6272-6272.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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