AZ-23

CAT: 0804-HY-15590-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15590-01Size:5 mg
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Description
AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
CAS Number
[915720-21-7]
Product Name Alternative
AZD1332
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ-23.html
Purity
98.92
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(OC1=CC(NC2=NC(N[C@H](C3=NC=C(F)C=C3)C)=NC=C2Cl)=NN1)C
Molecular Formula
C17H19ClFN7O
Molecular Weight
391.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8 (7) :1818-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB

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