AZ'3137

CAT: 0804-HY-162702-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-162702-01Size:5 mg
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Description
AZ‘3137 is an orally active PROTAC-type androgen receptor (AR) degrader with a DC50 value of 22 nM. AZ‘3137 can degrade L702H mutant AR (DC50 of 92 nM) . AZ'3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Pink: AR Ligand (HY-172954) ; Blue: CRBN ligand (HY-172955) ; Black: linker (HY-W262798) ; E3 Ligand+Linker: HY-172956) [1].
CAS Number
[2960179-55-7]
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az-3137.html
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=CC(N2CCN(CC3CCN(C4=CC=C(C5CCN(C6=CC=C(C#N)C(C(F)(F)F)=C6F)CC5)C=C4)CC3)CC2)=CC7=C1C(N(C8CCC(NC8=O)=O)C7)=O
Molecular Formula
C43H47F4N7O4
Molecular Weight
801.87
References & Citations
[1]Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67 (14) :11732-11750.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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