AZ 11645373

• Description :

  AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors, AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H318, H335

• Target :

  P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/az-11645373.html

• Concentration :

  10mM

• Purity :

  99.54

• Solubility :

  DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(N1C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC4=CC=NC=C4)SCC1=O

• Molecular Formula :

  C24H21N3O5S

• Molecular Weight :

  463.51

• Precautions :

  H315, H318, H335

• References & Citations :

  [1]Stokes L, et al. Characterization of a selective and potent antagonist of human P2X (7) receptors, AZ11645373. Br J Pharmacol. 2006 Dec;149 (7) :880-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [227088-94-0]