PPARγ-IN-3

CAT: 0804-HY-161985Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161985Size:1 Each
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Description
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity[1].
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pparγ-in-3.html
Smiles
COC1=CC=C(NC(C2=NC(C)=C(F)C(NCCN3CCCC3)=N2)=C4/C=N/NC(OC)=O)C4=C1
Molecular Formula
C23H28FN7O3
Molecular Weight
469.51
References & Citations
[1]Wei LY, et al. Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents. Eur J Med Chem. 2024 Nov 5;277:116773.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ

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