BTK degrader-1

BTK degrader-1

• CAS Number: 2377645-56-0
• UNSPSC Description: BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect[1].
• Target Antigen: ADC Cytotoxin; Btk
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/btk-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C(C)(C)O)C=C1F)NC2=CC(F)=CC(C3=C4C=C(C5=CC=C(CCN6CCC7(CC6)CCN(CC7)C(C8=CC=C(C(N9C(NC(CC9)=O)=O)=C8)OC)=O)C=C5)NC4=NC=N3)=C2C
• Molecular Weight: 925.03
• References & Citations: [1]Alan Zhang, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79bTargeted Antibody–Drug Conjugates. Bioconjug Chem. 2024 Feb 21;35(2):140-146.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported