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HIF-1α-IN-4

CAT: 0804-HY-151465-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151465-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell) . HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer[1].
CAS Number
2826221-23-0
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1α-in-4.html
Purity
99.95
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(C(C)=O)C=C3
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
References & Citations
[1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF) -1α Inhibitors. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Hif-1|A-IN-4
CAS Number2826221-23-0
PubChem CID165412813
IUPAC NameN-(4-acetylphenyl)-1,2-benzoxazole-3-carboxamide
Molecular FormulaC16H12N2O3
Molecular Weight280.28
XLogP2.6
Topological Polar Surface Area72.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity404
SMILES
CC(=O)C1=CC=C(C=C1)NC(=O)C2=NOC3=CC=CC=C32
InChI
InChI=1S/C16H12N2O3/c1-10(19)11-6-8-12(9-7-11)17-16(20)15-13-4-2-3-5-14(13)21-18-15/h2-9H,1H3,(H,17,20)
InChIKey
PLIVETCICWRHCP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hif-1|A-IN-4
CAS: 2826221-23-0
CID: 165412813
Formula: C16H12N2O3
MW: 280.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.28
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass280.08479225
Monoisotopic Mass280.08479225
Topological Polar Surface Area72.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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GTR19187947-01HIF-1α-IN-4
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