YM158 (free base)

• UNSPSC Description:

  YM158 free base is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.

• Target Antigen:

  Leukotriene Receptor; Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Benzamide,_N-[5-[3-[_4-chlorophenyl_sulfonyl]propyl]-2-_2H-tetrazol-5-ylmethoxy_phenyl]-3-[[4-_1,1-dimethylethyl_-2-thiazolyl]methoxy]-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC(CCCS(=O)(C2=CC=C(Cl)C=C2)=O)=CC=C1OCC3=NN=NN3)C4=CC=CC(OCC5=NC(C(C)(C)C)=CS5)=C4

• Molecular Weight:

  681.22

• References & Citations:

  [1]Arakida Y, et al. In vitro pharmacologic profile of YM158, a new dual antagonist for LTD₄ and TXA₂ receptors. J Pharmacol Exp Ther. 1998 Nov;287(2):633-9.|[2]Arakida Y, et al. Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs. J Pharmacol Exp Ther. 1999 Sep;290(3):1285-91.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  179102-65-9