KRP-105

• Description:

  KRP-105 is a potent, highly selective, and orally effective PPAR alpha (EC50 = 8 nM) agonist. KRP-105 can significantly reduce serum triglyceride, total cholesterol, and non high density lipoprotein cholesterol levels. KRP-105 can be used for research on metabolic diseases such as dyslipidemia[1].

• UNSPSC:

  12352005

• Target:

  PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Smiles:

  OC(C1=CC=CC(N(CCC2)C[C@H]2NC(C3=C(C)N=C(C4=CC=C(C=C4)Cl)S3)=O)=C1)=O

• Molecular Formula:

  C23H22ClN3O3S

• Molecular Weight:

  455.96

• References & Citations:

  [1]Nomura M, et al. Discovery of cyclic amine-substituted benzoic acids as PPARα agonists. Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :334-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PPARα

• CAS Number:

  [876145-69-6]