KRP-297

• Description :

  KRP-297 is a PPARα and PPARγ agonist potentially for the research of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver.

• Product Name Alternative :

  MK-0767

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/krp-297.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC(CC2SC(NC2=O)=O)=CC=C1OC)NCC3=CC=C(C=C3)C(F)(F)F

• Molecular Formula :

  C20H17F3N2O4S

• Molecular Weight :

  438.42

• References & Citations :

  [1]Murakami K, Tobe K, Ide T, et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes. 1998;47 (12) :1841-1847. |[2]Kochansky CJ, Rippley RK, Yan KX, et al. Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5- (2,4-dioxo-5-thiazolidinyl) -N-[[4- (trifluoromethyl) phenyl] methyl]benzamide) in humans. Drug Metab Dispos. 2006;34 (9) :1457-1461.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [213252-19-8]