KRP-297

CAT: 0804-HY-119248-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119248-01Size:1 mg
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Description
KRP-297 is a PPARĪ± and PPARĪ³ agonist potentially for the research of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver.
CAS Number
[213252-19-8]
Product Name Alternative
MK-0767
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/krp-297.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(CC2SC(NC2=O)=O)=CC=C1OC)NCC3=CC=C(C=C3)C(F)(F)F
Molecular Formula
C20H17F3N2O4S
Molecular Weight
438.42
References & Citations
[1]Murakami K, Tobe K, Ide T, et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes. 1998;47 (12) :1841-1847. |[2]Kochansky CJ, Rippley RK, Yan KX, et al. Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5- (2,4-dioxo-5-thiazolidinyl) -N-[[4- (trifluoromethyl) phenyl] methyl]benzamide) in humans. Drug Metab Dispos. 2006;34 (9) :1457-1461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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