NTRC-844

• Description:

  NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2), with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research[1].

• UNSPSC:

  12352005

• Target:

  Neurotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ntrc-844.html

• Purity:

  95.60

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=NN(C(C=C2)=CC=C2F)C(C(C=CC=C3)=C3OC)=C1)NC4([C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)C(O)=O

• Molecular Formula:

  C28H28FN3O4

• Molecular Weight:

  489.54

• References & Citations:

  [1]James B Thomas, et al. Identification of 2- ({[1- (4-Fluorophenyl) -5- (2-methoxyphenyl) -1H-pyrazol-3-yl]carbonyl}amino) tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1225-31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1811503-67-9