NTRC-824

• Description :

  NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM) [1].

• UNSPSC :

  12352005

• Target :

  Neurotensin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ntrc-824.html

• Purity :

  98.2

• Smiles :

  CC(C)C[C@@H](C(O)=O)NC(CN1C=C(C(C(F)(F)F)=O)C2=C1C=CC(NS(=O)(C3=CC=C(C)C=C3)=O)=C2)=O

• Molecular Formula :

  C25H26F3N3O6S

• Molecular Weight :

  553.55

• References & Citations :

  [1]Thomas JB, et al. Identification of N-[ (5-{[ (4-methylphenyl) sulfonyl]amino}-3- (trifluoroacetyl) -1H-indol-1-yl) acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11;57 (17) :7472-7.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NTR2

• CAS Number :

  [1623002-61-8]