NTRC-824

• Description:

  NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM) [1].

• UNSPSC:

  12352005

• Target:

  Neurotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ntrc-824.html

• Purity:

  98.2

• Smiles:

  CC(C)C[C@@H](C(O)=O)NC(CN1C=C(C(C(F)(F)F)=O)C2=C1C=CC(NS(=O)(C3=CC=C(C)C=C3)=O)=C2)=O

• Molecular Formula:

  C25H26F3N3O6S

• Molecular Weight:

  553.55

• References & Citations:

  [1]Thomas JB, et al. Identification of N-[ (5-{[ (4-methylphenyl) sulfonyl]amino}-3- (trifluoroacetyl) -1H-indol-1-yl) acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11;57 (17) :7472-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NTR2

• CAS Number:

  [1623002-61-8]