XL-844

• Description :

  XL-844 (EXEL-9844) is an inhibitor of Chk1 and Chk2. XL-844 exhibits antineoplastic activity. XL-844 can result in tumor cell apoptosis through inhibition of cell cycle arrest. XL-844 inhibits VEGFR1 and VEGFR3. XL-844 can be studied in anti-cancer research[1].

• CAS Number :

  [631864-00-1]

• Product Name Alternative :

  EXEL-9844

• UNSPSC :

  12352005

• Target :

  Checkpoint Kinase (Chk)

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C(NC1=NC=CN=C1)NC2=CC=CC=C2OCCCN

• Molecular Formula :

  C14H17N5O2

• Molecular Weight :

  287.32

• References & Citations :

  [1]Riesterer O, et al., A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. Invest New Drugs. 2011 Jun;29 (3) :514-22

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported