XL-844

• Description:

  XL-844 (EXEL-9844) is an inhibitor of Chk1 and Chk2. XL-844 exhibits antineoplastic activity. XL-844 can result in tumor cell apoptosis through inhibition of cell cycle arrest. XL-844 inhibits VEGFR1 and VEGFR3. XL-844 can be studied in anti-cancer research[1].

• Product Name Alternative:

  EXEL-9844

• UNSPSC:

  12352005

• Target:

  Checkpoint Kinase (Chk)

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C(NC1=NC=CN=C1)NC2=CC=CC=C2OCCCN

• Molecular Formula:

  C14H17N5O2

• Molecular Weight:

  287.32

• References & Citations:

  [1]Riesterer O, et al., A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. Invest New Drugs. 2011 Jun;29 (3) :514-22

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  631864-00-1