NTRC-808

• Description :

  NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC50 of 14 nM and Ki of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity[1].

• UNSPSC :

  12352005

• Target :

  Neurotensin Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  CC(C)C[C@@H](C(O)=O)NC(C1=NC(C2=C(OC)C=CC=C2OC)=C3C=C(Cl)C=CC3=N1)=O

• Molecular Formula :

  C23H24ClN3O5

• Molecular Weight :

  457.91

• References & Citations :

  [1]J. B. Thomas et al. Identification of N-{[6-chloro-4- (2,6-dimethoxyphenyl) quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Med. Chem. Lett. 25 (2015) 292-296.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1643879-88-2]