NTRC-808

• Description:

  NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC50 of 14 nM and Ki of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity[1].

• UNSPSC:

  12352005

• Target:

  Neurotensin Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  CC(C)C[C@@H](C(O)=O)NC(C1=NC(C2=C(OC)C=CC=C2OC)=C3C=C(Cl)C=CC3=N1)=O

• Molecular Formula:

  C23H24ClN3O5

• Molecular Weight:

  457.91

• References & Citations:

  [1]J. B. Thomas et al. Identification of N-{[6-chloro-4- (2,6-dimethoxyphenyl) quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Med. Chem. Lett. 25 (2015) 292-296.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1643879-88-2