844-TFM

• Description :

  844-TFM is a NBTI (novel bacterial topoisomerase inhibitor) DNA gyrase inhibitor, with an IC50 of 1.5 μM. 844-TFM exhibits bactericidal properties against M. abscessus[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/844-tfm.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C2N=CC=C(C2=N1)NC(C3CCN(CC3)CCC4=CC=C(C=C4)C(F)(F)F)=O

• Molecular Formula :

  C24H25F3N4O2

• Molecular Weight :

  458.48

• References & Citations :

  [1]Beuchel A, et, al. Structure-Activity Relationship of Anti- Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors. ACS Med Chem Lett. 2022 Feb 28;13 (3) :417-427.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2767443-97-8]