844-TFM

• UNSPSC Description:

  844-TFM is a NBTI (novel bacterial topoisomerase inhibitor) DNA gyrase inhibitor, with an IC50 of 1.5 μM. 844-TFM exhibits bactericidal properties against M. abscessus[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/844-tfm.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C2N=CC=C(C2=N1)NC(C3CCN(CC3)CCC4=CC=C(C=C4)C(F)(F)F)=O

• Molecular Weight:

  458.48

• References & Citations:

  [1]Beuchel A, et, al. Structure-Activity Relationship of Anti- Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors. ACS Med Chem Lett. 2022 Feb 28;13(3):417-427.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2767443-97-8