NTRC-739

• Description:

  NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC50 of 12 nM and a Ki of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research[1].

• UNSPSC:

  12352005

• Target:

  Neurotensin Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C1(NC(C2=NN(C3=CC=C(F)C=C3)C(C4=CC=CC=C4OC)=C2)=O)CCCCC1)O

• Molecular Formula:

  C24H24FN3O4

• Molecular Weight:

  437.46

• References & Citations:

  [1]Thomas JB, et al. Identification of 1- ({[1- (4-fluorophenyl) -5- (2-methoxyphenyl) -1H-pyrazol-3-yl]carbonyl}amino) cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem. 2014 Jun 26;57 (12) :5318-32.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NTR2

• CAS Number:

  [1612188-96-1]