Flurbiprofen-d4

• Description:

  Flurbiprofen-d4 is deuterated labeled Flurbiprofen (HY-10582) . Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

• Product Name Alternative:

  Dl-Flurbiprofen-d4

• UNSPSC:

  12352005

• Target:

  Apoptosis; COX; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(C2=CC=CC=C2)C=CC(C([2H])(C([2H])([2H])[2H])C(O)=O)=C1

• Molecular Formula:

  C15H9D4FO2

• Molecular Weight:

  248.29

• References & Citations:

  [1]Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.|[2]Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20 (5) : 132.|[3]E M Glenn, et al. The pharmacology of 2- (2-fluoro-4-biphenylyl) propionic acid (flurbiprofen) . A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3 (4) :210-6.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported