Flurbiprofen-d3

• Description:

  Flurbiprofen-d3 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

• Product Name Alternative:

  Dl-Flurbiprofen-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H335, H361

• Target:

  Apoptosis; COX

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Cancer

• Purity:

  99.87

• Solubility:

  DMSO : ≥ 100mg/mL

• Smiles:

  FC1=CC(C(C(O)=O)C([2H])([2H])[2H])=CC=C1C2=CC=CC=C2

• Molecular Formula:

  C15H10D3FO2

• Molecular Weight:

  247.28

• Precautions:

  H301, H315, H319, H335, H361

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20 (5) : 132.|[3]E M Glenn, et al. The pharmacology of 2- (2-fluoro-4-biphenylyl) propionic acid (flurbiprofen) . A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3 (4) :210-6.|[4]Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1185133-81-6]