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Flurbiprofen axetil

CAT: 0804-HY-101481-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101481-01Size:5 mg
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Description
Flurbiprofen axetil is a non-selective COX inhibitor and a nonsteroidal anti-inflammatory agent with anti-inflammatory and analgesic effects. Flurbiprofen axetil inhibits basal-like breast cancer metastasis by inhibiting the MEK/ERK signaling pathway. Flurbiprofen axetil can promote neuroprotection after focal cerebral ischemia in rats by partially activating PPAR-γ. Flurbiprofen axetil alleviates cerebral ischemia/reperfusion injury by reducing inflammation in a transient global cerebral ischemia/reperfusion rat model. Flurbiprofen axetil can alleviate inflammatory responses and cognitive function in a mild cognitive impairment (MCI) SD rat model through the AMPKα/NF-κB signaling pathway[1][2][3][4][5].
CAS Number
91503-79-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Apoptosis; COX; ERK; Interleukin Related; MEK; NF-κB; PPAR; STAT; TNF Receptor; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/flurbiprofen-axetil.html
Purity
99.34
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(OC(OC(C)=O)C)C(C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
Molecular Formula
C19H19FO4
Molecular Weight
330.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Shen J, et al. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect. Int J Pharm. 2011 Jun 30;412 (1-2) :115-22.|[2]Zhu Y, et al. Flurbiprofen axetil is involved in basal-like breast cancer metastasis via suppressing the MEK/ERK signaling pathway. Cell Biol Int. 2025 Jan;49 (1) :68-78.|[3]Liu JL, et al. Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. Chin Med J (Engl) . 2012 Oct;125 (20) :3719-24. |[4]Wu H, et al. Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. Biosci Rep. 2018 Jul 6;38 (4) :BSR20171562. |[5]Huang L, et al. Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway. Ann Transl Med. 2022 Nov;10 (22) :1210.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX

Chemical Information

Flurbiprofen Axetil

Flurbiprofen axetil is an organic molecular entity.

CAS Number91503-79-6
PubChem CID3395
IUPAC Name1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate
Molecular FormulaC19H19FO4
Molecular Weight330.3
XLogP4.9
Topological Polar Surface Area52.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count24
Formal Charge0
Complexity433
SMILES
CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OC(C)OC(=O)C
InChI
InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3
InChIKey
ALIVXCSEERJYHU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flurbiprofen Axetil
CAS: 91503-79-6
CID: 3395
Formula: C19H19FO4
MW: 330.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight330.3
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass330.12673725
Monoisotopic Mass330.12673725
Topological Polar Surface Area52.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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561579Flurbiprofen Axetil
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A13662-25Flurbiprofen Axetil 25mg
A13662-5Flurbiprofen Axetil 5mg
A13662-50Flurbiprofen Axetil 50mg
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A13662-10Flurbiprofen Axetil 10mg
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