(S) -Flurbiprofen

• Description :

  (S) -Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1].

• Product Name Alternative :

  Esflurbiprofen

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  COX; PGE synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/s-flurbiprofen.html

• Purity :

  99.88

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)[C@@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

• Molecular Formula :

  C15H13FO2

• Molecular Weight :

  244.26

• Precautions :

  H301

• References & Citations :

  [1]A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36 (6) :505-12.|[2]B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S (+) -flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52 (12) :519-23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  COX-1; COX-2

• CAS Number :

  [51543-39-6]