Flurbiprofen

• Description:

  Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

• Product Name Alternative:

  Dl-Flurbiprofen

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Apoptosis; COX

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Flurbiprofen.html

• Purity:

  99.98

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  FC1=C(C2=CC=CC=C2)C=CC(C(C)C(O)=O)=C1

• Molecular Formula:

  C15H13FO2

• Molecular Weight:

  244.26

• Precautions:

  H301

• References & Citations:

  [1]Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.|[2]Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20 (5) : 132.|[3]E M Glenn, et al. The pharmacology of 2- (2-fluoro-4-biphenylyl) propionic acid (flurbiprofen) . A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3 (4) :210-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  COX; COX-1; COX-2

• CAS Number:

  [5104-49-4]