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4'-Hydroxy flurbiprofen

CAT: 0804-HY-118133-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118133-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM[1].
CAS Number
52807-12-2
UNSPSC
12352005
Hazard Statement
H301
Target
COX; Drug Metabolite
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroxy-flurbiprofen.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(C2=CC=C(C=C2)O)C(F)=C1)C(O)=O
Molecular Formula
C15H13FO3
Molecular Weight
260.26
Precautions
H301
References & Citations
[1]Karlsson J, Fowler CJ. Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen. PLoS One. 2014 Jul 25;9 (7) :e103589.|[2]Tracy TS, et al. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 1996 Oct 25;52 (8) :1305-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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