4'-Hydroxy flurbiprofen

• Description:

  4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  COX; Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/4-hydroxy-flurbiprofen.html

• Purity:

  99.28

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(C1=CC=C(C2=CC=C(C=C2)O)C(F)=C1)C(O)=O

• Molecular Formula:

  C15H13FO3

• Molecular Weight:

  260.26

• Precautions:

  H301

• References & Citations:

  [1]Karlsson J, Fowler CJ. Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen. PLoS One. 2014 Jul 25;9 (7) :e103589.|[2]Tracy TS, et al. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 1996 Oct 25;52 (8) :1305-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [52807-12-2]