MEK/RAF-IN-1

• UNSPSC Description:

  MEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC50 values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer[1].

• Target Antigen:

  MEK; Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mek-raf-in-1.html

• Smiles:

  FC1=C(NC2=C(F)C=C(C3CC3)C=C2)C(C(NOCCO)=O)=CC4=C1N=CN4CC5=C(F)C(NS(=O)(NCC)=O)=CC=C5

• Molecular Weight:

  618.63

• References & Citations:

  [1]Gonzalez-Del Pino GL, et al. Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2107207118.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported