MEK/RAF-IN-1

MEK/RAF-IN-1

• UNSPSC Description: MEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC50 values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer[1].
• Target Antigen: MEK; Raf
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mek-raf-in-1.html
• Smiles: FC1=C(NC2=C(F)C=C(C3CC3)C=C2)C(C(NOCCO)=O)=CC4=C1N=CN4CC5=C(F)C(NS(=O)(NCC)=O)=CC=C5
• Molecular Weight: 618.63
• References & Citations: [1]Gonzalez-Del Pino GL, et al. Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2107207118.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported