RAF-IN-1

• Target:

  Raf|||Others

• Related Pathways:

  Others|||MAPK

• Bioactivity:

  RAF-IN-1 is a potent inhibitor of b/cRAF, acting on cRAF (IC50: 3.8 nM), bRAFwt (IC50: 36 nM), and bRAFV600E (IC50: 29.4 nM), and inhibiting A375 and H358 cell lines carrying the bRAFV600E mutation with a GI50 of 3.4 and 2.9 nM, respectively.

• Smiles:

  O=C1NC2(OC=3C1=CC=C(C3)C4=CC(NC(=O)C=5C=C(C(F)(F)F)N=CC5)=CC=C4C)CCOCC2

• Molecular Formula:

  C26H22F3N3O4

• Molecular Weight:

  497.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2695505-82-7