RAF-IN-1

RAF-IN-1

• CAS Number: 2695505-82-7
• UNSPSC Description: RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].
• Target Antigen: Raf
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/raf-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2
• Molecular Weight: 497.47
• References & Citations: [1]Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported