RAF-IN-1

• Description :

  RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].

• UNSPSC :

  12352005

• Target :

  Raf

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/raf-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2

• Molecular Formula :

  C26H22F3N3O4

• Molecular Weight :

  497.47

• References & Citations :

  [1]Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  B-Raf; C-Raf

• CAS Number :

  [2695505-82-7]