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RAF mutant-IN-1

CAT: 0804-HY-126298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126298Size:1 Each
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Description
RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively[1].
CAS Number
2340020-82-6
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/raf-mutant-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CSC2=C(N)N=CN=C21)NC3=C(C)C=CC4=C3C=CN=C4NC5=CC=C(O)C(Cl)=C5F.[H]Cl.[H]Cl
Molecular Formula
C23H18Cl3FN6O2S
Molecular Weight
567.85
References & Citations
[1]BAE, In Hwan, et al. Title of Invention: THIENO[3,2-d]PYRIMIDINE COMPOUND HA VING INHIBITORY ACTIVITY FOR PROTEIN KINASE. WO2019107987A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf

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