MEK/PI3K-IN-1

MEK/PI3K-IN-1

• CAS Number: 2281803-28-7
• UNSPSC Description: MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].
• Target Antigen: MEK; PERK; PI3K
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;MAPK/ERK Pathway;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mek-pi3k-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCNC3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3
• Molecular Weight: 913.63
• References & Citations: [1]Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported