MEK1/C-Raf-IN-1

• UNSPSC Description:

  MEK1/C-Raf-IN-1 (Compound 14d) is a MEK1/C-Raf inhibitor with IC50 values of 97 and 23 nM, respectively. MEK1/C-Raf-IN-1 has antitumor activity[1].

• Target Antigen:

  MEK; Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mek1-c-raf-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OC4=NC=CC=N4)=C2

• Molecular Weight:

  470.47

• References & Citations:

  [1]Hyohdoh I, et al. Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties. ACS Med Chem Lett. 2013 Sep 22;4(11):1059-63.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  946128-76-3