3,3'-Diindolylmethane

• UNSPSC Description:

  3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

• Target Antigen:

  Androgen Receptor; Autophagy

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3,3_acute_-Diindolylmethane.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4

• Molecular Weight:

  246.313

• References & Citations:

  [1]Le HT, et al. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003 Jun 6;278(23):21136-45.|[2]Li XJ, et al. 3,3'-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway. Oncol Rep. 2013 Nov;30(5):2419-26.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 4

• CAS Number:

  1968-05-4