LY127210 (free base)

CAT: 0804-HY-129706Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-129706Size:1 Each

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Description

LY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance[1].

CAS Number

57184-68-6

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ly127210-free-base.html

Smiles

NC1=NC=CC2=CC(OC)=C(OC)C=C2C1

Molecular Formula

C12H14N2O2

Molecular Weight

218.25

References & Citations

[1]Steinberg MI, et al. Hemodynamic and vascular activity of LY127210, a new vasodilator, in anesthetized spontaneously hypertensive rats: comparison with hydralazine. Clin Exp Hypertens A. 1985;7 (10) :1481-97.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

LY-127210 free base

CAS Number	57184-68-6
PubChem CID	146401
IUPAC Name	7,8-dimethoxy-1H-3-benzazepin-2-amine
Molecular Formula	C12H14N2O2
Molecular Weight	218.25
XLogP	0.9
Topological Polar Surface Area	56.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	16
Formal Charge	0
Complexity	301

SMILES

COC1=C(C=C2C=CN=C(CC2=C1)N)OC

InChI

InChI=1S/C12H14N2O2/c1-15-10-5-8-3-4-14-12(13)7-9(8)6-11(10)16-2/h3-6H,7H2,1-2H3,(H2,13,14)

InChIKey

WADYQLCXAVXCQZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 57184-68-6

CID: 146401

Formula: C12H14N2O2

MW: 218.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	218.25
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	218.105527694
Monoisotopic Mass	218.105527694
Topological Polar Surface Area	56.8 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	301
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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LY127210 (free base)

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