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HJC0152 (free base)

CAT: 0804-HY-W369099Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W369099Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].
CAS Number
1420290-88-5
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hjc0152-free-base.html
Solubility
10 mM in DMSO
Smiles
NCCOC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C([N+](=O)[O-])C=C2
Molecular Formula
C15H13Cl2N3O4
Molecular Weight
370.19
References & Citations
[1]Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4 (2) :180-185.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
CAS Number1420290-88-5
PubChem CID71527596
IUPAC Name2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
Molecular FormulaC15H13Cl2N3O4
Molecular Weight370.2
XLogP2.9
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity449
SMILES
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)OCCN
InChI
InChI=1S/C15H13Cl2N3O4/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17/h1-4,7-8H,5-6,18H2,(H,19,21)
InChIKey
DIMJVBOEXNWPOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
CAS: 1420290-88-5
CID: 71527596
Formula: C15H13Cl2N3O4
MW: 370.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight370.2
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass369.0283113
Monoisotopic Mass369.0283113
Topological Polar Surface Area110 Ų
Heavy Atom Count24
Formal Charge0
Complexity449
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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