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HJC0152 (free base)

CAT: 0804-HY-W369099Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W369099Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].
CAS Number
1420290-88-5
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hjc0152-free-base.html
Solubility
10 mM in DMSO
Smiles
NCCOC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C([N+](=O)[O-])C=C2
Molecular Formula
C15H13Cl2N3O4
Molecular Weight
370.19
References & Citations
[1]Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4 (2) :180-185.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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