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Flavone

CAT: 0804-HY-N2424-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2424-01Size:500 mg
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Description
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3) . Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer[1][2][3].
CAS Number
525-82-6
Product Name Alternative
2-Phenyl-4-chromone
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H401
Target
Apoptosis; Caspase; CDK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flavone.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13
Molecular Formula
C15H10O2
Molecular Weight
222.24
Precautions
H315, H319, H335, H401
References & Citations
[1]Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9 (4) :263-85.|[2]Zhang Q, et al. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 Aug;23 (5) :797-807.|[3]Liu S, et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol. 2006 Sep;6 (9) :1387-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; CDK1

Chemical Information

Flavone

Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide.

CAS Number525-82-6
PubChem CID10680
IUPAC Name2-phenylchromen-4-one
Molecular FormulaC15H10O2
Molecular Weight222.24
XLogP3.6
Topological Polar Surface Area26.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity326
SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
InChI
InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
InChIKey
VHBFFQKBGNRLFZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flavone
CAS: 525-82-6
CID: 10680
Formula: C15H10O2
MW: 222.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight222.24
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass222.068079557
Monoisotopic Mass222.068079557
Topological Polar Surface Area26.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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