Flavone

• Description:

  Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3) . Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer[1][2][3].

• Product Name Alternative:

  2-Phenyl-4-chromone

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335, H401

• Target:

  Apoptosis; Caspase; CDK

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flavone.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13

• Molecular Formula:

  C15H10O2

• Molecular Weight:

  222.24

• Precautions:

  H315, H319, H335, H401

• References & Citations:

  [1]Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9 (4) :263-85.|[2]Zhang Q, et al. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 Aug;23 (5) :797-807.|[3]Liu S, et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol. 2006 Sep;6 (9) :1387-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3; Caspase 9; CDK1

• CAS Number:

  [525-82-6]