Flavone

CAT: 0804-HY-N2424-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2424-01Size:500 mg
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Description
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3) . Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer[1][2][3].
CAS Number
[525-82-6]
Product Name Alternative
2-Phenyl-4-chromone
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H401
Target
Apoptosis; Caspase; CDK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flavone.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13
Molecular Formula
C15H10O2
Molecular Weight
222.24
Precautions
H315, H319, H335, H401
References & Citations
[1]Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9 (4) :263-85.|[2]Zhang Q, et al. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 Aug;23 (5) :797-807.|[3]Liu S, et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol. 2006 Sep;6 (9) :1387-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; CDK1

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