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Flavonol

CAT: 0804-HY-107825-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107825-01Size:500 mg
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Description
Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases[1][2][3][4].
CAS Number
[577-85-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Bacterial; Cholinesterase (ChE) ; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/flavonol.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=CC=C13
Molecular Formula
C15H10O3
Molecular Weight
238.24
Precautions
H315, H319, H335
References & Citations
[1] Huang YH, et al. Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol. Protein J. 2015 Jun;34 (3) :169-72. |[2]Guo AJ, et al. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chem Biol Interact. 2010 Sep 6;187 (1-3) :246-8. |[3]Kim HK, et al. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol. 1999 Sep 1;58 (5) :759-65. |[4]Sayeli V, et al. Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice. Inflammopharmacology. 2019 Dec;27 (6) :1155-1167. |[5]Phie J, et al. Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. PLoS One. 2017 Jul 25;12 (7) :e0181832.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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