Flavanone

• Description:

  Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) . Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H290, H314

• Target:

  Cytochrome P450; ERK; MMP; NF-κB; p38 MAPK; PAI-1

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flavanone.html

• Purity:

  99.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1CC(C2=CC=CC=C2)OC3=CC=CC=C13

• Molecular Formula:

  C15H12O2

• Molecular Weight:

  224.26

• Precautions:

  H290, H314

• References & Citations:

  [1]JT Kellis Jr, et al. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep. 225 (4666) :1032-1034.|[2]Hsiao YC, et al., Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 May 1;167 (3) :193-206.|[3]Hsiao YC, et al., The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. J Biomed Sci. 2007 Jan;14 (1) :107-19.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Aromatase/CYP19A1

• CAS Number:

  [487-26-3]