Flavanone

• Description :

  Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) . Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].

• CAS Number :

  [487-26-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H290, H314

• Target :

  Cytochrome P450; ERK; MMP; NF-κB; p38 MAPK; PAI-1

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/flavanone.html

• Purity :

  99.73

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1CC(C2=CC=CC=C2)OC3=CC=CC=C13

• Molecular Formula :

  C15H12O2

• Molecular Weight :

  224.26

• Precautions :

  H290, H314

• References & Citations :

  [1]JT Kellis Jr, et al. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep. 225 (4666) :1032-1034.|[2]Hsiao YC, et al., Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chem Biol Interact. 2007 May 1;167 (3) :193-206.|[3]Hsiao YC, et al., The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. J Biomed Sci. 2007 Jan;14 (1) :107-19.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Aromatase/CYP19A1