Totrombopag

Totrombopag

• CAS Number: 376592-42-6
• UNSPSC Description: Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology[1].
• Target Antigen: Thrombopoietin Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/totrombopag.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=NN5)=CC=C4)=CC=C3)C
• Molecular Weight: 466.49
• References & Citations: [1]Alper P B, et al. Discovery and biological evaluation of benzo [a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor[J]. Bioorganic & medicinal chemistry letters, 2008, 18(19): 5255-5258.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 1