BTA-188

• Description:

  BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae[1].

• UNSPSC:

  12352005

• Target:

  Enterovirus; Virus Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bta-188.html

• Smiles:

  CCO/N=C/C(C=C1)=CC=C1OCCC(CC2)CCN2C3=NN=C(C)C=C3

• Molecular Formula:

  C21H28N4O2

• Molecular Weight:

  368.47

• References & Citations:

  [1]D L Barnard, et al. In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity. Antimicrob Agents Chemother. 2004 May;48 (5) :1766-72.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [314062-80-1]