Anticancer agent 188

• Description :

  Anticancer agent 188 (compound D43) inhibits DNA synthesis in TNBC cells, leading to cell cycle arrest at the G2/M phase. Anticancer agent 188 has anti-cancer viability by inducing ROS-mediated apoptosis and DNA damage[1].

• CAS Number :

  [1207377-56-7]

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-188.html

• Purity :

  99.10

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CN1C(C2=NC(C3=C(F)C=CC=C3)=N1)=NC(N(C)C2=O)=O

• Molecular Formula :

  C13H10FN5O2

• Molecular Weight :

  287.25

• References & Citations :

  [1]Tingyue Wu, et al. Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducin. Sci Rep. 2024, 14, 1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported