Keap1-Nrf2-IN-22

Keap1-Nrf2-IN-22

• CAS Number: 2955083-85-7
• UNSPSC Description: Keap1-Nrf2-IN-22 (compound 19) is a Keap1-Nrf2 inhibitor， with a KD2 value of 42.2 nM for Keap1. Keap1-Nrf2-IN-22 can be used for the study of acute lung injury (ALI) and cerebral ischemia/reperfusion (I/R) injury[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-22.html
• Smiles: O=S(C1=CC(C=CC=C2)=C2C=C1)(N(CC(O)=O)C3=CC(C4=CC=C(C(O)=O)N4CC)=CC=C3)=O
• Molecular Weight: 478.52
• References & Citations: [1]Tang J, et al. Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment. Bioorg Chem. 2024 Aug 31;153:107741.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported