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EM20-25

CAT: 0804-HY-101999Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101999Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine , and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069).
CAS Number
141266-44-6
UNSPSC
12352005
Hazard Statement
H400
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/em20-25.html
Smiles
O=C1NC(C(C2C3=CC(Cl)=CC=C3OC(NC(N4)=O)=C2C4=O)C(N1)=O)=O
Molecular Formula
C15H9ClN4O6
Molecular Weight
376.71
Precautions
P273-P391-P501
References & Citations
[1]Milanesi E, et al., The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem. 2006 Apr 14;281 (15) :10066-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 9

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