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RET-IN-25

CAT: 0804-HY-156113Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156113Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RET-IN-25 (compound 6b) is a RET kinase inhibitor with anticancer activity. RET-IN-25 inhibits medullary thyroid carcinoma (MTC) with IC50s of 3.6 μM (3 days) and 3.0 μM (6 days) against TT (C634R) MTC[1].
CAS Number
2965703-02-8
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-25.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(SC2=C1C=NC3=CC=C(C=C32)[N+]([O-])=O)C(OCC)=O)C4=CC=C(C)C=C4
Molecular Formula
C22H17N3O5S
Molecular Weight
435.45
References & Citations
[1]La Monica G, et al. Design and Synthesis of Novel Thieno [3, 2-c] quinoline Compounds with Antiproliferative Activity on RET-Dependent Medullary Thyroid Cancer Cells[J]. ACS Omega, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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