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BPK-25

CAT: 0804-HY-141550-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141550-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1].
CAS Number
2305052-86-0
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bpk-25.html
Purity
99.88
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(N(CC1=NC(Cl)=CC=C1)C2=CN=C(C(NC3=CC=CC=C3)=O)C=C2)C=C
Molecular Formula
C21H17ClN4O2
Molecular Weight
392.84
References & Citations
[1]Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182 (4) :1009-1026.e29.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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