TR-100

• Description:

  TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm) . TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion[1][2].

• UNSPSC:

  12352005

• Target:

  Arp2/3 Complex

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tr-100.html

• Purity:

  99.0

• Smiles:

  O=C(NCCCCCCCC)/C(C#N)=C/C1=C(C)N(CCCN(C)C)C2=C1C=CC=C2

• Molecular Formula:

  C26H38N4O

• Molecular Weight:

  422.61

• References & Citations:

  [1]Hill T A, et al. Inhibition of Dynamin Mediated Endocytosis by the Dynoles--Synthesis and Functional Activity of a Family of Indoles[J]. Journal of medicinal chemistry, 2009, 52 (12) : 3762-3773.|[2]Kee A J, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism[J]. Scientific reports, 2018, 8 (1) : 4604.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1128165-86-5]