TR-213

CAT: 0804-HY-177743Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177743Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK) . TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].
CAS Number
[2980502-40-5]
UNSPSC
12352005
Target
CDK; DNA/RNA Synthesis; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1
Molecular Formula
C22H20N4O3
Molecular Weight
388.42
References & Citations
[1]Sano O, et al. Novel quinazolin-4 (3H) -one based Cyclin K degraders regulate alternative polyadenylation activity. Biochem Biophys Res Commun. 2023 Oct 8;676:6-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P3459Tet-213
HY-107712-01TCN 213
HY-P991358XOMA-213
HY-14327-01FAUC 213
HY-W999584CRBN ligand-213
HY-158373Anticancer agent 213
HY-163528Antibacterial agent 213
HY-P3459A-01Tet-213 (TFA)
HY-15770-01TR-14035
HY-124689-01TR-100

Alternative Products

CatalogName
MD108108-4Tr-PEG4-Tr
B5628-100ML 213
B5536-10TCN 213
C4770-50AG-213
sc-484832ML-213
sc-252820FAUC 213
pro-2075NCS1 213 a.a.
M24286-01FAUC-213
MF-0155889-01Tet-213

Popular Products