TR-213

• Description:

  TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK) . TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].

• UNSPSC:

  12352005

• Target:

  CDK; DNA/RNA Synthesis; Molecular Glues

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Field of Research:

  Cancer

• Smiles:

  N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1

• Molecular Formula:

  C22H20N4O3

• Molecular Weight:

  388.42

• References & Citations:

  [1]Sano O, et al. Novel quinazolin-4 (3H) -one based Cyclin K degraders regulate alternative polyadenylation activity. Biochem Biophys Res Commun. 2023 Oct 8;676:6-12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2980502-40-5