Tr-PEG5-OH

• Description:

  Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

• UNSPSC:

  12352203

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tr-peg5-oh.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OCCOCCOCCOCCOCCOC (C1=CC=CC=C1) (C2=CC=CC=C2) C3=CC=CC=C3

• Molecular Formula:

  C29H36O6

• Molecular Weight:

  480.59

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Branderhorst HM, et al. Strong inhibition of cholera toxin binding by galactose dendrimers. Chem Commun (Camb) . 2007 Dec 21; (47) :5043-5.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Non-cleavable Linker; PEG Linkers

• CAS Number:

  141282-24-8