TR-100

• Target:

  Arp2/3 Complex

• Related Pathways:

  Cytoskeletal Signaling

• Bioactivity:

  TR-100 is a small molecule inhibitor targeting tumor-associated tropomyosin (Tpm) . It binds to the C-terminus of Tpm3.1, affecting its interaction with actin filaments and thus influencing their stability and function. This mechanism allows TR-100 to specifically affect actin filament bundles in cancer cells without impairing cardiac muscle function. TR-100 is useful for studying the role of Tpm3.1 in cancer cell proliferation and survival, as well as its impact on insulin-stimulated glucose uptake and insulin secretion.

• Smiles:

  N#CC(=CC=1C=2C=CC=CC2N(C1C)CCCN(C)C)C(=O)NCCCCCCCC

• Molecular Formula:

  C26H38N4O

• Molecular Weight:

  422.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1128165-86-5