PD-321852

• Description :

  PD-321852 is a Chk1 inhibitor, with IC50 of 5 nM. PD-321852 can be used in anti-cancer research[1].

• UNSPSC :

  12352005

• Target :

  Checkpoint Kinase (Chk)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pd-321852.html

• Smiles :

  O=C1NC(C2=C(C3=C(N4CCCNC)C=CC(O)=C3)C4=CC(C5=C(Cl)C=CC=C5Cl)=C21)=O

• Molecular Formula :

  C24H19Cl2N3O3

• Molecular Weight :

  468.33

• References & Citations :

  [1]Parsels LA, et al. Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Mol Cancer Ther. 2009 Jan;8 (1) :45-54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Chk1

• CAS Number :

  [622856-21-7]