HG-7-85-01-NH2

• UNSPSC Description:

  HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].

• Target Antigen:

  Bcr-Abl; Ligands for Target Protein for PROTAC; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hg-7-85-01-nh2.html

• Purity:

  99.20

• Solubility:

  DMSO : 125 mg/mL (ultrasonic;adjust pH to 5 with H2O)

• Smiles:

  O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(N)=N5)=N4)=C3

• Molecular Weight:

  540.60

• References & Citations:

  [1]Shibata N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018 Sep 10;8(1):13549.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1258391-29-5